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PARADISE-MI: Sacubitril/Valsartan Fails to Show Superiority over Ramipril
Similar outcomes observed after acute myocardial infarction Patients with previous myocardial infarction (MI) who are also diagnosed with lung and cardiac deficiencies do not appear to gain an advantage from treatment with sacubitril/valsartan compared with ramipril in preventing further cardiac deterioration, researchers reported. After a follow-up of 23 months, 338 primary en...
Physician's Weekly 2 years ago
ACC: Analysis Finds Heart and Kidney Disease May Come Before T2D in Pre-Diabetes
Consider full glycemic spectrum when assessing risk Diabetes is a well-recognized risk factor for cardiovascular disease (CVD), but pre-diabetes is often overlooked in CVD prevention efforts, even though it is more common than diabetes. And, although treatment guidelines such as the Standards of Medical Care in Diabetes–2019 and its 2021 update—as well as the 2019 [...
Physician's Weekly 2 years ago
First Episode Psychosis: Psychiatric or Neurologic?
Autoimmune psychosis is rare and depends on neurological features Even when cerebrospinal fluid (CSF) was tested, patients with first episode psychosis did not have a high frequency of N-methyl-d-aspartate receptor (NMDAR) antibodies, a prospective study found. The frequency of NMDAR antibodies in CSF was about the same as it was when measured in serum, reported […]...
Physician's Weekly 2 years ago
ACC: DARE-19 Finds SGLT2i Tx Does Not Significantly Reduce Organ Damage in Covid-19
Less organ decompensation and fewer deaths, but not statistically significant As a class, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have consistently demonstrated benefit—initially as a treatment for type 2 diabetes, and eventually as a class of drugs that can also protect the heart and kidneys in persons with or without diabetes. Consider this list of what [R...
Physician's Weekly 2 years ago
AMA Asks Congress to Act on Prior Authorization Reform
Organization cites pandemic roadblocks, throws weight behind Improving Seniors’ Timely Access to Care Act CHICAGO—The American Medical Association (AMA) asked Congress to tackle the issue of prior authorization after an AMA survey found that the “unnecessary, bureaucratic obstacles” impeded patient care during the Covid-19 pandemic. Three years ago, the ...
Physician's Weekly 2 years ago
High Ozone Exposure May Increase Uterine Fibroid Risk in Black Women
Multiple studies suggest a link between air pollution and fibroids Black women exposed to elevated levels of ozone from air pollution had an increased risk for developing uterine fibroids in a large, prospective cohort study with 14 years of follow-up. Women with the highest ozone exposures had a 35% increased risk for uterine fibroids compared […]...
Physician's Weekly 2 years ago
ACC: Trial Confirms Aspirin Efficacy for Secondary Prevention But Fails to Identify Optimal Dose
ADAPTIVE trial confirms ASA can reduce ischemic events without significant bleeding risk Which daily aspirin dose (81 mg or 325 mg) is more effective at preventing cardiovascular death, myocardial infarction (MI), and/or stroke in persons with cardiovascular disease? For those who were eagerly awaiting the answer to this question, there is now an answer: Neither. […]...
Physician's Weekly 2 years ago
Automated OCT Measurements of Central Macular Fluid Volume Increase Accuracy of DME Dx
AI results promising, but not yet ready for prime time In the future, automated optical coherence tomography (OCT) measurements of central macular fluid volume (CMFV) may give clinicians more accuracy in diagnosing diabetic macular edema (DME), the predominant cause of visual impairment in patients with diabetes, according to a study published in JAMA Ophthalmology. But, [̷...
Physician's Weekly 2 years ago
Genetic Profile Refines Risk of SCD in Patients with Left Ventricular Systolic Dysfunction
For carriers of FLNCtv, prophylactic ICD threshold may be higher Identifying the genetic drivers of dilated cardiomyopathy (DCM)—which truncating variant is the patient carrying, the gene encoding filamin C (FLNCtv) or the one encoding TTN (TTNtv)—may be a more reliable way to assess true risk of sudden cardiac death or end-stage heart failure than simply […]...
Physician's Weekly 2 years ago
Medical News Forecast for May 17-23
Lynne Peterson is the Senior Writer for Trends-in-Medicine. Here is the medical news to watch for May 17-23, 2021. Cardiology The American College of Cardiology (ACC) virtual meeting ends on May 17, but that last day will have sessions on original research in pediatric and congenital heart disease, mechanical support for heart failure and cardiomyopathies, […]...
Physician's Weekly 2 years ago